10 Best Patient Management Software for 2025: Top Picks

Patient management software continues to evolve as an essential tool for modern clinics and practices. These platforms centralize administrative functions like scheduling, billing, communication, and analytics to streamline workflows and elevate patient care. In 2025, selecting a system hinges on how well it balances usability, integration with clinical systems, and value for money.

Below are detailed reviews of the 10 leading patient management platforms—each evaluated for their strengths, limitations, and verified user feedback from G2.

What Makes the Best Patient Management Software?

To identify the best patient management software, we evaluated dozens of platforms across criteria including:

• Features: Core patient management system features such as scheduling, billing, portals, and reporting.
• Ease of Use: Whether staff can quickly adopt and navigate the system.
• Integrations: How well the software connects with EHRs, CRMs, telehealth, and billing platforms.
• Support: The quality of customer service, onboarding, and ongoing training.
• Pricing: Affordability and flexibility of plans for practices of different sizes.
• Ratings: User feedback from sites like G2 and Capterra to ensure real-world validation.
  
  

The top 10 vendors below represent the best patient case management software and patient relationship management software for 2025.

Best Patient Management Software Programs for 2025: Reviews

1. Athenahealth

Athenahealth offers a cloud-based suite called athenaOne, combining EHR, practice management, billing, and care coordination into a unified platform while enabling interoperability across multiple care settings. Its intuitive design supports clinical efficiency through features like real-time daily schedules and inbox views, which help providers stay focused on patient care.

Top Features

• Integrated EHR and practice management
• Real-time scheduling and inbox dashboards
• Advanced billing and claims processing modules
  
  

Pros

• Highly intuitive and improves provider productivity
• Strong interoperability and real-time clinical visibility
• Hands-on customer support including 24/7 access and custom training
  
  

Cons

• Learning curve can be steep for new users
• Pricing based on revenue share makes costs less transparent
  
  

Reviews

Athenahealth (athenaOne) holds approximately a 4.7/5 rating on G2, indicating high user satisfaction.

2. AdvancedMD

AdvancedMD provides a scalable, cloud-native platform rooted in seamless patient scheduling, customizable clinical templates, and intuitive billing workflows—especially useful for mid-sized and larger practices.

Top Features

• Specialty-specific customizable EHR templates
• Built-in billing, revenue cycle, and patient portal
• Task management tools like “Task Donuts”
  
  

Pros

• Fast implementation with smooth information migration
• Highly customizable workflows ideal for multi-provider environments
  
  

Cons

• Can be complex to navigate initially
• Average G2 satisfaction score is lower than competitors
  
  

Reviews

AdvancedMD averages a 3.6/5 rating on G2, with praise for features but noted room for usability improvement.

3. Tebra (formerly Kareo + PatientPop)

Tebra unifies practice management, billing, EHR integration, and patient engagement in a single, modern interface tailored to independent clinics. Its user-friendly portal supports streamlined patient intake, reminders, and feedback workflows.

Top Features

• Digital intake forms and task automation
• HIPAA-compliant messaging and patient outreach tools
  
  

Pros

• Highly intuitive and mobile-friendly
• Strong customer support and quick onboarding
• Excellent patient engagement tools
  
  

Cons

• Advanced features are sometimes limited
• Reporting capabilities could be expanded
  
  

Reviews

Tebra holds a 4.1/5 rating on G2 with positive user sentiment on ease of use and support.

4. DrChrono

DrChrono blends EHR, PMS, and billing into a robust, mobile-first platform, especially popular among practices leveraging iPad-based workflows. It streamlines charting and administrative procedures for enhanced efficiency.

Top Features

• Native iPad app for charting and intake
• Automated billing and claims
• Patient scheduling and portal access
  
  

Pros

• Excellent mobility feature set
• Integrates EHR and PMS seamlessly
  
  

Cons

• Reporting workflows may require additional setup
• Some features require deeper technical familiarity
  
  

Reviews

DrChrono earns positive reviews on G2 with ratings around 4.6, especially for its mobile capabilities.

5. NextGen Healthcare

NextGen caters to multi-specialty and growing practices with configurable workflows, specialty-specific templates, and strong compliance features.

Top Features

• Specialty-tailored documentation tools
• Multi-practice billing and scheduling workflows
• Built-in compliance and reporting support
  
  

Pros

• Flexible and highly customizable to different specialties
• Strong regulatory support for compliance
  
  

Cons

• Implementation can be lengthy for full functionality
• Complexity may overwhelm smaller practice teams
  
  

Reviews

NextGen Healthcare maintains approximately a 4.4/5 rating on G2.

6. Solutionreach

Solutionreach is built specifically to improve patient communication and engagement, offering tools like reminders, surveys, and recall outreach modules.

Top Features

• HIPAA-compliant automated appointment reminders
• Two-way secure messaging
• Patient satisfaction surveys and recall campaigns
  
  

Pros

• Proven to reduce no-shows and increase retention
• Excellent patient experience features
  
  

Cons

• Does not provide robust billing or PMS functionality
• Requires integration with a separate practice management system
  
  

Reviews

Solutionreach scores around 4.4/5 among users for improving communication and practice engagement.

7. Lumeon

Lumeon automates patient care workflows across touchpoints—ideal for organizations seeking structured personalization across care episodes, including reminders and task assignments.

Top Features

• Care pathway automation
• Task tracking and assignment
• Patient experience orchestration
  
  

Pros

• Powerful automation engine for adaptable workflows
• Improves care coordination at scale
  
  

Cons

• Best for practices with internal IT teams due to complexity
• Higher setup effort for full automation deployment
  
  

Reviews

User ratings on G2 approximate 4.3/5 for workflow automation and custom care coordination systems.

8. CareCloud

CareCloud offers a modern, cloud-first PMS and billing platform with sharp financial analytics and easy-to-use interfaces.

Top Features

• Financial dashboards and practice performance insights
• Patient scheduling and reminders
• Integrated billing tools
  
  

Pros

• Visually clear and scalable
• Strong analytics capabilities
  
  

Cons

• More expensive compared to tools for small clinics
  
  

Reviews

CareCloud holds a 4.3/5 rating on G2, with high marks for design and functionality.

9. eClinicalWorks

eClinicalWorks delivers a unified clinical and administrative solution, covering EHR, PMS, portals, telehealth, and lab interactions.

Top Features

• Patient portal with telehealth
• Integrated scheduling, billing, and documentation
  
  

Pros

• Feature-rich for full clinical practice integration
• Seamless end-to-end patient workflow support
  
  

Cons

• Complexity can be challenging for smaller teams
• Significant implementation planning required
  
  

Reviews

eClinicalWorks achieves a solid 4.2/5 on G2 reflective of its comprehensive feature set.

10. Meditech Expanse

Meditech Expanse offers a comprehensive PMS and clinical ecosystem tailored to hospitals or multi-clinic organizations seeking unified systems across patient care and admin functionality.

Top Features

• Integrated EHR, PMS, and patient portals across departments
  
  

Pros

• Seamless clinical and administrative workflows across hospital systems
• Built for enterprise-scale operations
  
  

Cons

• Not optimized for small independent clinics
• Implementation and training require significant planning
  
  

Reviews

Expanse typically receives ratings above 4/5 in hospital-based use cases.

Patient Management System Features to Look For

Appointment Scheduling

Easy-to-use and flexible scheduling, with automated reminders, ensures high patient attendance and improved provider utilization. Efficient scheduling significantly reduces administrative workload.

Billing Integration

A well-integrated billing system—automating claims submission, coding, and revenue tracking—reduces errors and accelerates reimbursement, making your practice more financially efficient.

Patient Portals

Secure patient portals empower individuals to access their records, book, or interact with providers, which enhances patient satisfaction and decreases administrative phone traffic.

Telehealth Support

Built-in telehealth functionality allows you to deliver virtual care seamlessly—a must-have feature in today’s healthcare landscape to maintain continuity and flexibility.

Reporting and Analytics

Actionable dashboards provide insights into critical metrics such as revenue, no-show rates, and care bottlenecks, helping practices optimize operations and improve patient outcomes.

Compliance

Robust HIPAA and GDPR compliance features protect patient data and reduce the risk of audits and fines while maintaining trust in your organization’s digital health systems.

Conclusion

Small practices may find Tebra (formerly Kareo) or DrChrono to offer affordability and agility. Mid-sized and growing practices benefit from platforms like Athenahealth, AdvancedMD, or CareCloud offering scalability. Multispecialty clinics may lean into NextGen or Meditech Expanse. If the goal is improving patient engagement, Solutionreach and Lumeon stand out for communications and workflow automation.

Aligning your priorities—be it usability, billing efficiency, engagement, or scale—will guide you to the patient management software that perfectly matches your 2025 clinical strategy.

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